Genome Assembly & Sequencing Technologies

How raw sequencing reads become a genome — short-read vs. long-read platforms, de Bruijn graph assembly, and what coverage actually buys you.

Read

49 min

Practice MCQs

25

Interview QA

25

Edition

v3

Editorial status

Reviewed

Relevant for

Computational Biologist

Scope: Foundational Lander-Waterman and de Bruijn graph models; SPAdes, Canu, Flye, hifiasm, QUAST and BUSCO source publications; current Illumina, PacBio, Oxford Nanopore and NCBI guidance reviewed 2026-09-04.